In the immense universe, the interstellar gas and dust may seem insubstantial, but they are actually of crucial importance. From the stellar nursery within the Pillars of Creation in the Eagle Nebula to the flows of matter in the Milky Way, as revealed by infrared and radio observations; from the violent ejection of matter back into interstellar space by the Supernova 1987A to the Sun's ultimate fate of becoming a planetary nebula - the pervading interstellar medium is both the stage and the raw material for the life-and-death cycle of stars. In the interstellar journey with this fulldome film, we will jointly witness a scientific epic that uncovers the cosmic cycle of matter and explores the foundation of life's origins.